Drugging the undruggable RAS: Mission possible?
AD Cox, SW Fesik, AC Kimmelman, J Luo… - Nature reviews Drug …, 2014 - nature.com
Despite more than three decades of intensive effort, no effective pharmacological inhibitors
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
C Kadoch, GR Crabtree - Science advances, 2015 - science.org
Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …
Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study
Background Activating enhancer of zeste homolog 2 (EZH2) mutations or aberrations of the
switch/sucrose non-fermentable (SWI/SNF) complex (eg, mutations or deletions of the …
switch/sucrose non-fermentable (SWI/SNF) complex (eg, mutations or deletions of the …
[HTML][HTML] SMARCA4-deficient thoracic sarcomatoid tumors represent primarily smoking-related undifferentiated carcinomas rather than primary thoracic sarcomas
Introduction Highly aggressive thoracic neoplasms characterized by SMARCA4 (BRG1)
deficiency and undifferentiated round cell or rhabdoid morphology have been recently …
deficiency and undifferentiated round cell or rhabdoid morphology have been recently …
Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)
WG McCluggage, N Singh, CB Gilks - Histopathology, 2022 - Wiley Online Library
An updated World Health Organization (WHO) classification of female genital tumours was
published in autumn 2020. We discuss the major new additions to and changes from the …
published in autumn 2020. We discuss the major new additions to and changes from the …
SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy
K Mardinian, JJ Adashek, GP Botta, S Kato… - Molecular cancer …, 2021 - AACR
The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
[HTML][HTML] A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of …
Purpose Despite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer
predisposition, there is limited guidance surrounding indications for testing and genes to …
predisposition, there is limited guidance surrounding indications for testing and genes to …
[HTML][HTML] A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for …
H Hampel, RL Bennett, A Buchanan, R Pearlman… - Genetics in …, 2015 - Elsevier
Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a
histologically and genetically broad range of tumours, including those of epithelial, sex cord …
histologically and genetically broad range of tumours, including those of epithelial, sex cord …
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas
While investigating cohorts of unclassified sarcomas by RNA sequencing, we identified 19
cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin …
cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin …