Innate immune evasion strategies of SARS-CoV-2
JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
Innate immune sensing of coronavirus and viral evasion strategies
The innate immune system is the first line of the host defense program against pathogens
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
AK Reuschl, LG Thorne, MVX Whelan… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
Roles and functions of SARS-CoV-2 proteins in host immune evasion
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …
SARS-CoV-2 biology and host interactions
S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …
genome encodes some accessory proteins that are essential for infection. Notably …
[HTML][HTML] SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
M Shemesh, TE Aktepe, JM Deerain, JL McAuley… - PLoS …, 2021 - journals.plos.org
Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
Mechanisms of antiviral immune evasion of SARS-CoV-2
DK Beyer, A Forero - Journal of molecular biology, 2022 - Elsevier
Abstract Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …