Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …

Guanine-rich DNA sequences may fold back into non-canonical four-stranded secondary
structures termed as G-quadruplexes. The role of G-quadruplexes has already been well …

Background c-Kit protein is a signal transduction protein involved in multiple signal
pathways, which play an important role in a variety of cellular events such as cell …

G-quadruplexes (G4s) within the human genome have undergone extensive molecular
investigation, with a strong focus on telomeres, gene promoters and repetitive regulatory …

The prion protein (PrP) misfolding to its infectious form is critical to the development of prion
diseases, whereby various ligands are suggested to participate, such as copper and nucleic …

Introduction G-quadruplexes (G4s) are secondary structures formed in guanine-rich regions
of nucleic acids (both DNA and RNA). G4s are significantly enriched at regulatory genomic …

Nucleic acid aptamers are innovative and promising candidates to block the hallmark event
in the prion diseases, that is the conversion of prion protein (PrP) into an abnormal form; …

After four decades of prion protein research, the pressing questions in the literature remain
similar to the common existential dilemmas. Who am I? Some structural characteristics of the …

Prion diseases are prototype of infectious diseases transmitted by a protein, the prion
protein (PrP), and are still not understandable at the molecular level. Heterogenous species …

Gene therapy is a powerful approach to promote spinal cord regeneration. For a clinical
application it is important to restrict therapeutic gene expression to the appropriate time …