Innate immunity is not only the first line of host defense against microbial infections but is
also crucial for the host responses against a variety of noxious stimuli. Z-DNA binding …

Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic
complications, which seriously affect the quality of life and physical and mental health of …

The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still
unknown, which represents a limitation for its broader use. Further, not knowing the effects …

Skeletal muscle is a promising tissue for therapeutic gene delivery because it is highly
vascularized, accessible, and capable of synthesizing protein for therapies or vaccines. The …

Background: Tissues, such as skeletal muscle, have been targeted for the delivery of
plasmid DNA (pDNA) encoding vaccines and therapeutics. The application of electric pulses …

Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United
States and is under development in many other countries. Acute changes in endogenous …

Local intratumor delivery with electroporation of low levels of plasmids encoding molecules,
induces an antitumor effect without causing systemic toxicity. However, previous studies …

Gene therapy approaches may target skeletal muscle due to its high protein-expressing
nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric …

Fluorescent reporter genes are widely used to study the transfection of various types of
primary cells and cell lines. The aim of our research was to investigate the expression …

Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United
States and is under development in many other countries. Acute changes in endogenous …