Astrocytes, the largest and most numerous glial cells in the central nervous system (CNS),
play a variety of important roles in regulating homeostasis, increasing synaptic plasticity and …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

Biochemical and neuropathological studies of brains from individuals with Alzheimer
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …

Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Traumatic brain injury (TBI) is seen by the insurance industry and many health care
providers as an “event.” Once treated and provided with a brief period of rehabilitation, the …

Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds,
APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs) …

Mild TBI (mTBI) is a significant health concern. Animal models of mTBI are essential for
understanding mechanisms, and pathological outcomes, as well as to test therapeutic …

Traumatic brain injury (TBI) constitutes a major global health and socio-economic problem
with neurobehavioral sequelae contributing to long-term disability. It causes brain swelling …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Microglia are resident immune cells in the central nervous system (CNS) that originate from
myeloid progenitor cells in the embryonic yolk sac and are maintained independently of …