There are limited studies on long-term outcomes of childhood onset nephrotic syndrome
(NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS) …

Glucocorticoids are a general class of steroids that possess renoprotective activity in
glomeruli through their interaction with the glucocorticoid receptor. However, the …

Glucocorticoid receptor (GR) is expressed in normal renal podocytes; however, its
expression differs among renal diseases. The expression of GR as well as its epigenetic …

Glucocorticoids are primary therapy of idiopathic nephrotic syndrome (INS). However, not all
children respond to steroid therapy. We assessed glomerular glucocorticoid receptor …

Steroid‐resistant nephrotic syndrome (SRNS) is a clinical challenge with variable clinical
outcomes. In patients with SRNS, unsuccessful anti‐inflammatory and anti‐proteinuric …

汞是常见的重金属毒物, 多种原因导致的急慢性汞中毒可对人体多个脏器产生严重损害.
临床上因汞中毒导致的肾病逐年增多, 其损伤机制尚不明确, 治疗手段有限 …

Purpose Nephrotic syndrome (NS) is the most common form of glomerulopathy in children.
Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS …

A wide variety of pharmacologic agents having diverse mechanisms of action and potential
adverse events are widely used in treatment of primary glomerular diseases. However, the …

Little was known about the relationships between the T lymphocytes (CD3+), expression of
glucocorticoid receptors (GCR) and the response to GC treatment in children with the …

Glomerular podocytes are highly differentiated epithelial cells that play a pivotal role in
kidney filtration. Alpha-actinin 4 (ACTN4) is a well-known actin-binding protein and a critical …