The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

Bioactive micro-and macro-molecules (postbiotics) derived from gut beneficial microbes are
among natural chemical compounds with medical significance. Currently, a unique …

Abstract Sigma-1 receptor (S1R) has been considered a promising therapeutic target for
several neurodegenerative diseases and S1R agonists have shown neuroprotective activity …

This article summarizes historic developments, recent expert opinions, and (currently)
unresolved challenges concerning the Biopharmaceutics Classification System (BCS) …

In October 2016, the International Council for Harmonisation of Technical Requirements for
Pharmaceuticals for Human Use (ICH) ICH began efforts to provide recommendations to …

Purpose: To review in vitro testing and simulation platforms that are in current use to predict
in vivo performances of generic products as well as other situations to provide evidence for …

The use of apex vessels may solve coning problems associated with dissolution testing.
However, excessive dissolution acceleration can reduce the discriminatory power. This …

The present work aimed to explain the differences in oral performance in fasted humans
who were categorized into groups based on the three different drug product formulations of …

Objective To determine the in vitro and in vivo absorption properties of active ingredients of
the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug …

Recently, the diarylurea scaffold has been used widely to design potential anticancer
agents. Pursuing our design strategy based on the modification of sorafenib as the lead …