Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …

Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …

Nearly 25% of US adults report concurrently taking a prescription medication with a dietary
supplement. Some supplements, such as St. John's wort and goldenseal, are known to …

Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk
thistle, Silymarin and silybin, are the most prescribed natural compounds, with different …

This article provides an overview of the clinical evidence of interactions between herbal and
conventional medicines. Herbs involved in drug interactions–or that have been evaluated in …

According to current US Food and Drug Administration (FDA) and European Medicines
Agency (EMA) guidance documents, physiologically based pharmacokinetic (PBPK) …

Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …

The use of herbal/botanical products, also referred to as complementary and alternative
medicines (CAM), worldwide enjoys increasing popularity. It appears in particular highly …

In Part 2 of this review, a critical examination of the pertinent scientific literature is
undertaken in order to assess the interaction risk that popular dietary supplements may pose …