Animal models of major depression: drawbacks and challenges

B Planchez, A Surget, C Belzung - Journal of Neural Transmission, 2019 - Springer
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

BD Hare, RS Duman - Molecular psychiatry, 2020 - nature.com
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety

WZ Liu, WH Zhang, ZH Zheng, JX Zou, XX Liu… - Nature …, 2020 - nature.com
Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …

Treatment resistant depression: a multi-scale, systems biology approach

H Akil, J Gordon, R Hen, J Javitch, H Mayberg… - Neuroscience & …, 2018 - Elsevier
An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

[HTML][HTML] Corticoamygdala transfer of socially derived information gates observational learning

SA Allsop, R Wichmann, F Mills, A Burgos-Robles… - Cell, 2018 - cell.com
Observational learning is a powerful survival tool allowing individuals to learn about threat-
predictive stimuli without directly experiencing the pairing of the predictive cue and …

[图书][B] Being brains: making the cerebral subject

F Vidal, F Ortega - 2020 - degruyter.com
Being Brains Skip to content Should you have institutional access? Here's how to get it ... De
Gruyter € EUR - Euro £ GBP - Pound $ USD - Dollar EN English Deutsch 0 Subjects Skip section …

O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

J Fan, F Guo, R Mo, LY Chen, JW Mo… - The Journal of …, 2023 - Am Soc Clin Investig
Major depressive disorder is a common and devastating psychiatric disease, and the
prevalence and burden are substantially increasing worldwide. Multiple studies of …

A shared vision for machine learning in neuroscience

MAT Vu, T Adalı, D Ba, G Buzsáki… - Journal of …, 2018 - Soc Neuroscience
With ever-increasing advancements in technology, neuroscientists are able to collect data in
greater volumes and with finer resolution. The bottleneck in understanding how the brain …

Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes, and future challenges in improving translation

J Deslauriers, M Toth, A Der-Avakian, VB Risbrough - Biological psychiatry, 2018 - Elsevier
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …

Brain-wide electrical spatiotemporal dynamics encode depression vulnerability

R Hultman, K Ulrich, BD Sachs, C Blount, DE Carlson… - Cell, 2018 - cell.com
Brain-wide fluctuations in local field potential oscillations reflect emergent network-level
signals that mediate behavior. Cracking the code whereby these oscillations coordinate in …