The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …

The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR) serves critical functions
in physiological and pathological processes in the central nervous system, including …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …

Binding, gating, a nity and e cacy Page 1 SEMINAR Binding, gating, a nity and e cacy The nature
of the problem Some history The classical era The interaction between binding and conformation …

Since the finding by Johnson and Ascher (1987) demonstrating that glycine enhances
electrophysiological responses mediated by N-methyl-D-aspartate (NMDA) b

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …