Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

[HTML][HTML] Thin films as an emerging platform for drug delivery

S Karki, H Kim, SJ Na, D Shin, K Jo, J Lee - Asian journal of pharmaceutical …, 2016 - Elsevier
Pharmaceutical scientists throughout the world are trying to explore thin films as a novel
drug delivery tool. Thin films have been identified as an alternative approach to conventional …

The basics and underlying mechanisms of mucoadhesion

JD Smart - Advanced drug delivery reviews, 2005 - Elsevier
Mucoadhesion is where two surfaces, one of which is a mucous membrane, adhere to each
other. This has been of interest in the pharmaceutical sciences in order to enhance localised …

Mucoadhesive polymeric platforms for controlled drug delivery

GP Andrews, TP Laverty, DS Jones - European journal of pharmaceutics …, 2009 - Elsevier
The process of mucoadhesion involving a polymeric drug delivery platform is a complex one
that includes wetting, adsorption and interpenetration of polymer chains amongst various …

The use of mucoadhesive polymers in ocular drug delivery

A Ludwig - Advanced drug delivery reviews, 2005 - Elsevier
In the present update on mucoadhesive ocular dosage forms, the tremendous advances in
the biochemistry of mucins, the development of new polymers, the use of drug complexes …

In vitro techniques to evaluate buccal films

AB Nair, R Kumria, S Harsha, M Attimarad… - Journal of Controlled …, 2013 - Elsevier
Extensive research on transmucosal drug delivery in the past few decades has resulted in
the clinical application of several drug molecules through the buccal route. Interestingly …

Bioadhesive‐based dosage forms: The next generation

JW Lee, JH Park, JR Robinson - Journal of pharmaceutical sciences, 2000 - Elsevier
Prolonged contact time of a drug with a body tissue, through the use of a bioadhesive
polymer, can significantly improve the performance of many drugs. These improvements …

Thiolated polymers—thiomers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates

CE Kast, A Bernkop-Schnürch - Biomaterials, 2001 - Elsevier
The aim of this study was to improve mucoadhesive properties of chitosan by the covalent
attachment of thiol moieties to this cationic polymer. Mediated by a carbodiimide, thioglycolic …

Comparison of the mucoadhesive properties of various polymers

V Grabovac, D Guggi, A Bernkop-Schnürch - Advanced drug delivery …, 2005 - Elsevier
In this study the mucoadhesive potential of nineteen different, most often referred
mucoadhesive polymers was evaluated and characterized by adhesion time and total work …

Polymers with thiol groups: a new generation of mucoadhesive polymers?

A Bernkop-Schnürch, V Schwarz, S Steininger - Pharmaceutical research, 1999 - Springer
Purpose. To improve the mucoadhesive properties of polycarbophil by the introduction of
sulfhydryl groups. Methods. Mediated by a carbodiimide, cysteine was covalently bound to …