The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …

Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural
components of cells. They also play important roles in the modulation of immune responses …

Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather
antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate …

Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic
influences in human dendritic cell biology and their ability to orchestrate immune responses …

Dendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on
capturing antigens coming from pathogens or tumors and presenting to T cells for immune …

Efficacy of cancer vaccines remains low and mechanistic understanding of antigen
presenting cell function in cancer may improve vaccine design and outcomes. Here, we …

Dendritic cells (DCs) undergo rapid metabolic reprogramming to generate signal-specific
immune responses. The fine control of cellular metabolism underlying DC immune tolerance …

Energy metabolism maintains the activation of intracellular and intercellular signal
transduction, and plays a crucial role in immune response. Under environmental stimulation …

Immune checkpoint inhibitors have ushered in a new era of cancer treatment by increasing
the likelihood of long-term survival for patients with metastatic disease and by introducing …