Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in
disease management, providing a stark contrast to traditional therapeutic approaches like …

Molecules that are able to induce proximity between two proteins are finding ever increasing
applications in chemical biology and drug discovery. The ability to introduce an electrophile …

The family of human-infecting coronaviruses (HCoVs) poses a serious threat to global health
and includes several highly pathogenic strains that cause severe respiratory illnesses. It is …

Reactive fragment (RF) screening has emerged as an efficient method for ligand discovery
across the proteome, irrespective of a target's perceived tractability. To date, however, the …

ABSTRACT Proteolysis-Targeting Chimeras (PROTACs) are a novel class of bifunctional
small molecules that alter protein levels by targeted degradation. This innovative approach …

Targeted protein degradation has been widely adopted as a new approach to eliminate both
established and previously recalcitrant therapeutic targets. Here, it is reported that the …

The spread of the influenza virus has caused devastating pandemics and huge economic
losses worldwide. Antiviral drugs with diverse action modes are urgently required to …

Viral proteases are an important target for drug development, since they can modulate vital
pathways in viral replication, maturation, assembly and cell entry. With the (re) appearance …

E3 ubiquitin ligases regulate the composition of the proteome. These enzymes mono-or poly-
ubiquitinate their substrates, directly altering protein function or targeting proteins for …

ABSTRACT Introduction Highly pathogenic coronaviruses (CoVs), such as severe acute
respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS …