Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

INTRODUCTION The hematopoietic road map is a compilation of the various lineage
differentiation routes that a stem cell takes to make blood. This program produces greater …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

The mammalian blood system, containing more than 10 distinct mature cell types, stands on
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large
granular lymphocytes that belong to the innate immune system because unlike T or B …

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells,
and natural killer (NK) cells remains controversial and constitutes an important gap in the …

The identification of distinct tissue-specific natural killer (NK) cell populations that apparently
mature from local precursor populations has brought new insight into the diversity and …

Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are
many variations on this basic theme. DCs differ in the regulatory signals they transmit …