In recent years, miR-124 has emerged as a critical modulator of immunity and inflammation.
Here, we summarize studies on the function and mechanism of miR-124 in the immune …

Cyclic nucleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP
and cGMP, reducing the signaling of these important intracellular second messengers …

Neuronal inflammation is the characteristic pathologic change of acute neurologic
impairment and chronic traumatic encephalopathy after traumatic brain injury (TBI) …

In our recent study, we observed consistent increases in miR-124-3p levels in exosomes
derived from cultured BV2 microglia which was treated with repetitive traumatic brain injury …

A number of chemotherapy drugs can induce autophagy. This inducible autophagy is a pro-
survival mechanism and contributes to the development of acquired drug resistance …

Inflammation is a response of the body to external stimuli (eg. chemical irritants, bacteria,
viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation …

Parkinson's disease (PD) is considered as a high prevalence neurodegenerative disorders
worldwide. Pathologically, the demise of dopamine-producing cells, in large part due to an …

Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory
activities. Synthetic GCs are widely used for managing chronic inflammatory and …

Background AKT2 is highly expressed in many human cancers, including non-small cell
lung cancer (NSCLC). Accumulating evidence has also revealed that AKT2 can promote …

MYC was found to be involved in many germinal center derived lymphomas, and more
recently in the histological transformation of indolent mature B-cell malignancies, such as …