Cognitive performance is typically conceptualized in terms of domains of functioning. These
domains are hierarchical in nature, with the bottom referring to more basic sensory and …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Adolescence is characterized by numerous social, hormonal and physical changes, as well
as a marked increase in risk-taking behaviors. Dual systems models attribute adolescent risk …

Objective: Many psychotropic medications used to treat schizophrenia have significant
anticholinergic properties, which are linked to cognitive impairment and dementia risk in …

The most replicated result in the field of intelligence is the positive manifold, which refers to
an all-positive pattern of correlations among diverse cognitive tests. The positive manifold is …

Objective: Schizophrenia is associated with a marked cognitive impairment that is widely
believed to remain stable after illness onset. Yet, to date, 10-year prospective studies of …

Objective: The lack of an accepted standard for measuring cognitive change in
schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing …

Abstract “Executive functions” is an umbrella term for functions such as planning, working
memory, inhibition, mental flexibility, as well as the initiation and monitoring of action. The …

Studies of neurocognitive function in patients with schizophrenia use widely variable
assessment techniques. Clinical trials assessing the cognitive enhancing effect of new …

One of the primary goals in the NIMH initiative to encourage development of new
interventions for cognitive deficits in schizophrenia, Measurement and Treatment Research …