Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

To evaluate the accuracy of biomarkers for the early diagnosis of biliary atresia (BA) and
prognostic stratification after Kasai portoenterostomy (KPE). We conducted a systematic …

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …

Connective tissue growth factor (CCN2) drives fibrogenesis in hepatic stellate cells (HSC).
Here we show that CCN2 up‐regulation in fibrotic or steatotic livers, or in culture‐activated …

Biliary atresia is a progressive infantile cholangiopathy of complex pathogenesis. Although
early diagnosis and surgery are the best predictors of treatment response, current diagnostic …

Biliary atresia is a rare disease but remains the most common indication for pediatric liver
transplantation as there are no effective medical therapies to slow progression after …

Cholestatic jaundice in early infancy is a complex diagnostic problem. Misdiagnosis of
cholestasis as physiologic jaundice delays the identification of severe liver diseases. In the …

Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and
extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice …

Development of reliable, noninvasive biomarkers that allow for diagnosis, risk stratification,
and monitoring of disease changes over time or in response to specific therapies represents …

Biliary atresia (BA) is a rare and severe inflammatory and obliterative cholangiopathy that
affects both extra-and intrahepatic bile ducts. BA symptoms occur shortly after birth with …