Emerging antifungal targets and strategies

M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …

Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials

J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

Honokiol improves depression-like behaviors in rats by HIF-1α-VEGF signaling pathway activation

XX Fan, WY Sun, Y Li, Q Tang, LN Li, X Yu… - Frontiers in …, 2022 - frontiersin.org
Increasing evidence indicates that the pathogenesis of depression is closely linked to
impairments in neuronal synaptic plasticity. Honokiol, a biologically active substance …

A Chinese herb preparation, honokiol, inhibits Streptococcus mutans biofilm formation

S Ren, Y Yang, M Xia, Y Deng, Y Zuo, L Lei, T Hu - Archives of Oral Biology, 2023 - Elsevier
Objective This study aimed to investigate the antibiofilm and anticariogenic effects of
honokiol, a traditional Chinese medicine, on the cariogenic bacterium Streptococcus mutans …

The application prospects of honokiol in dermatology

Y Li, C Liang, X Zhou - Dermatologic therapy, 2022 - Wiley Online Library
Honokiol is one of the natural extracts of Magnolia officinalis. It is a small molecule, lipophilic
compound with extensive biological effects. It has been used in the treatment of multisystem …

Recent developments on the anti-Candida effect of amphotericin B combined with a second drug - a mini-review

DCDE Moraes - Anais da Academia Brasileira de Ciências, 2023 - SciELO Brasil
Invasive Candida infections threaten human health due to the increasing incidence of
resistance to the currently available antifungal agents. Amphotericin B (AMB) is the gold …

Efficiently Synthesized, Multifunctional Recyclable Hydrogel for Accelerated Wound Healing

J Cui, X Su, B Jiao, W Xiang, Y Fang - ACS Applied Polymer …, 2024 - ACS Publications
Infections from bacteria and fungi, along with ongoing inflammation in chronic wounds, can
prolong the healing process and potentially lead to cancers. Hydrogel dressings, when used …

Magnolol inhibits Colletotrichum. gloeosporioides via disruption of plasma membrane and induction of reactive oxygen species accumulation

H Yang, X Yuan, Y Pan, Y Tan, Z Han, H Guan, S Wu… - Food Bioscience, 2024 - Elsevier
Colletotrichum gloeosporioides caused anthracnose in various tropical fruit, resulting in
substantial agricultural loss. Anthracnose diseases are mainly managed by chemical …

[HTML][HTML] Antifungal Activity of Tea Tree (Melaleuca alternifolia Cheel) Essential Oils against the Main Onychomycosis-Causing Dermatophytes

EM Álvarez, JV Rodríguez, OL Ripado… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Onychomycosis is a common fungal infection that affects the nails and accounts for
approximately 50% of all nail diseases. The main pathogens involved include …

[HTML][HTML] Active substances and molecular mechanisms of Astragali radix and Angelicae Sinensis radix against idiopathic pulmonary fibrosis effects by network …

CHU Haolin, LIU Shanshan, S ZHANG… - Chinese Journal of …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic disease with an unclear
etiology and no effective treatment. This study aims to elucidate the pathogenic mechanism …