From hybrid genomes to heterotic trait output: Challenges and opportunities

W Liu, Y Zhang, H He, G He, XW Deng - Current opinion in plant biology, 2022 - Elsevier
Heterosis (or hybrid vigor) has been widely used in crop seed breeding to improve many key
economic traits. Nevertheless, the genetic and molecular basis of this important …

A quantitative genetic framework highlights the role of epistatic effects for grain-yield heterosis in bread wheat

Y Jiang, RH Schmidt, Y Zhao, JC Reif - Nature genetics, 2017 - nature.com
Increasing wheat yield is a key global challenge to producing sufficient food for a growing
human population. Wheat grain yield can be boosted by exploiting heterosis, the superior …

Patterns of genome-wide allele-specific expression in hybrid rice and the implications on the genetic basis of heterosis

L Shao, F Xing, C Xu, Q Zhang, J Che… - Proceedings of the …, 2019 - National Acad Sciences
Utilization of heterosis has greatly increased the productivity of many crops worldwide.
Although tremendous progress has been made in characterizing the genetic basis of …

Hybrid vigor: the best of both parents, or a genomic clash?

D Bar-Zvi, O Lupo, AA Levy, N Barkai - Current Opinion in Systems Biology, 2017 - Elsevier
During evolution, mutations produce new lineages that gradually diverge in sequence and
regulatory properties. Related strains or species can hybridize to produce viable offspring …

Large-scale genomic and transcriptomic profiles of rice hybrids reveal a core mechanism underlying heterosis

J Xie, W Wang, T Yang, Q Zhang, Z Zhang, X Zhu, N Li… - Genome Biology, 2022 - Springer
Background Heterosis is widely used in agriculture. However, its molecular mechanisms are
still unclear in plants. Here, we develop, sequence, and record the phenotypes of 418 …

Dissecting a heterotic gene through GradedPool-Seq mapping informs a rice-improvement strategy

C Wang, S Tang, Q Zhan, Q Hou, Y Zhao… - Nature …, 2019 - nature.com
Hybrid rice breeding for exploiting hybrid vigor, heterosis, has greatly increased grain yield.
However, the heterosis-related genes associated with rice grain production remain largely …

easyGWAS: a cloud-based platform for comparing the results of genome-wide association studies

DG Grimm, D Roqueiro, PA Salomé… - The Plant …, 2017 - academic.oup.com
The ever-growing availability of high-quality genotypes for a multitude of species has
enabled researchers to explore the underlying genetic architecture of complex phenotypes …

The AraGWAS Catalog: a curated and standardized Arabidopsis thaliana GWAS catalog

M Togninalli, Ü Seren, D Meng, J Fitz… - Nucleic acids …, 2018 - academic.oup.com
The abundance of high-quality genotype and phenotype data for the model organism
Arabidopsis thaliana enables scientists to study the genetic architecture of many complex …

Genomic architecture of biomass heterosis in Arabidopsis

M Yang, X Wang, D Ren, H Huang… - Proceedings of the …, 2017 - National Acad Sciences
Heterosis is most frequently manifested by the substantially increased vigorous growth of
hybrids compared with their parents. Investigating genomic variations in natural populations …

Addressing Darwin's dilemma: can pseudo-overdominance explain persistent inbreeding depression and load?

DM Waller - Evolution, 2021 - academic.oup.com
Darwin spent years investigating the effects of self-fertilization, concluding that “nature
abhors perpetual self-fertilization.” Given that selection purges inbred populations of strongly …