The kidney is an important organ for the maintenance of Ca2+ homeostasis in the body.
However, disruption of Ca2+ homeostasis will cause a series of kidney diseases, such as …

Osteoporosis, a metabolic bone disorder characterized by decreased bone mass per unit
volume, poses a significant global health burden due to its association with heightened …

Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a
dismal prognosis, and despite significant advances in our understanding of its genetic …

Background Spermine is frequently elevated in tumor tissues and body fluids of cancer
patients and is critical for cancer cell proliferation, migration and invasion. However, the …

Stress is acknowledged as one of the major factors responsible for autophagy induction, a
tightly regulated process that acts as a pro-death or pro-survival mechanism within cells …

The calcium-sensing receptor (CaSR), abundantly expressed in the parathyroid gland and
kidney, plays a central role in calcium homeostasis. In addition, CaSR exerts multimodal …

Bone metastasis is a frequent complication for cancers and an important reason for the
mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life …

The calcium-sensing receptor (CaSR) is abundantly expressed in gastrointestinal mucosa
and participates in the regulation of feeding by affecting hormone secretion. Studies have …

The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-
surface-located receptor that can induce highly diffusible messengers (IP3, Ca2+, cAMP) in …

Cisplatin (DDP) is commonly used in the treatment of non-small cell lung cancer (NSCLC),
including lung adenocarcinoma (LUAD), and the primary cause for its clinical inefficacy is …