Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation

SK Mahata, A Corti - Annals of the New York Academy of …, 2019 - Wiley Online Library
Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects

KB Helle - Biological Reviews, 2004 - cambridge.org
The chromogranins A (CgA) and B (CgB) and secretogranin II (SgII) constitute the main
members of a family of uniquely acidic secretory proteins in elements of the diffuse …

Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.

JD Erickson, MK Schafer, TI Bonner… - Proceedings of the …, 1996 - National Acad Sciences
A second isoform of the human vesicular monoamine transporter (hVMAT) has been cloned
from a pheochromocytoma cDNA library. The contribution of the two transporter isoforms to …

Chromogranin A, an “on/off” switch controlling dense-core secretory granule biogenesis

T Kim, JH Tao-Cheng, LE Eiden, YP Loh - Cell, 2001 - cell.com
We present evidence that regulation of dense-core secretory granule biogenesis and
hormone secretion in endocrine cells is dependent on chromogranin A (CGA) …

Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis

C Hamelink, O Tjurmina, R Damadzic… - Proceedings of the …, 2002 - National Acad Sciences
The adrenal gland is important for homeostatic responses to metabolic stress: hypoglycemia
stimulates the splanchnic nerve, epinephrine is released from adrenomedullary chromaffin …

Localization of vesicular monoamine transporter isoforms (VMAT1 and VMAT2) to endocrine cells and neurons in rat

E Weihe, MKH Schäfer, JD Erickson… - Journal of Molecular …, 1994 - Springer
Polyclonal antipeptide antibodies have been raised against each of the two isoforms of the
rat vesicular monoamine transporter, VMAT1 and VMAT2. Antibody specificity was …

Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract

B Schütz, I Jurastow, S Bader, C Ringer… - Frontiers in …, 2015 - frontiersin.org
The mouse gastro-intestinal and biliary tract mucosal epithelia harbor choline
acetyltransferase (ChAT)-positive brush cells with taste cell-like traits. With the aid of two …

Granin-derived peptides

J Troger, M Theurl, R Kirchmair, T Pasqua, B Tota… - Progress in …, 2017 - Elsevier
The granin family comprises altogether 7 different proteins originating from the diffuse
neuroendocrine system and elements of the central and peripheral nervous systems. The …

Chromogranin A: current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway

AL Iacangelo, LE Eiden - Regulatory peptides, 1995 - Elsevier
The chromogranin/secretogranin proteins are acidic polypeptides, of apparent molecular
mass 70-120 kDa, found ubiquitously in the soluble matrix of dense-core secretory granules …

Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system

LE Eiden, VS Hernández, SZ Jiang, L Zhang - Cellular and Molecular Life …, 2022 - Springer
Neuropeptides are expressed in cell-specific patterns throughout mammalian brain.
Neuropeptide gene expression has been useful for clustering neurons by phenotype, based …