[HTML][HTML] Mitochondrial oxidative function in NAFLD: Friend or foe?
Background Mitochondrial oxidative function plays a key role in the development of non-
alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported …
alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported …
[HTML][HTML] Modulating lysosomal pH: a molecular and nanoscale materials design perspective
Lysosomes, membrane-bound organelles, play important roles in cellular processes
including endocytosis, phagocytosis, and autophagy. Lysosomes maintain cellular …
including endocytosis, phagocytosis, and autophagy. Lysosomes maintain cellular …
Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy
B Wei, J Pan, R Yuan, B Shao, Y Wang, X Guo… - Nano Letters, 2021 - ACS Publications
The tumor immunosuppressive microenvironment greatly limits the efficacy of
immunotherapy. Tumor-associated macrophages (TAMs) are the most abundant …
immunotherapy. Tumor-associated macrophages (TAMs) are the most abundant …
Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
Transcription factor EB (TFEB) mediates gene expression through binding to the
coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include …
coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include …
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders
Lysosomes play a central role in cellular homeostasis and alterations in this compartment
associate with many diseases. The most studied example is that of lysosomal storage …
associate with many diseases. The most studied example is that of lysosomal storage …
Mitochondrial mutations and genetic factors determining NAFLD risk
SA Dabravolski, EE Bezsonov, MS Baig… - International journal of …, 2021 - mdpi.com
NAFLD (non-alcoholic fatty liver disease) is a widespread liver disease that is often linked
with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes …
with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes …
The role of beta cell recovery in type 2 diabetes remission
M Suleiman, L Marselli, M Cnop, DL Eizirik… - International journal of …, 2022 - mdpi.com
Type 2 diabetes (T2D) has been considered a relentlessly worsening disease, due to the
progressive deterioration of the pancreatic beta cell functional mass. Recent evidence …
progressive deterioration of the pancreatic beta cell functional mass. Recent evidence …
Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells
DNA nanotechnology is a rapidly growing field that provides exciting tools for biomedical
applications. Targeting lysosomal functions with nanomaterials, such as DNA …
applications. Targeting lysosomal functions with nanomaterials, such as DNA …