Extensive research has shown that PR domain 16 (PRDM16) plays a critical role in adipose
tissue metabolism, including processes such as browning and thermogenesis of adipocytes …

Disruptions of blood pressure (BP) circadian variation are closely associated with an
increased risk of cardiovascular disease (CVD). Thus, gaining insights into the molecular …

Proper arterial versus venous endothelial lineage identity is required to establish a
hierarchical network of arteries and veins and prevent the occurrence of life-threatening …

PRDM16 is a transcription factor with histone methyltransferase activity expressed at the
earliest stages of cardiac development. Pathogenic mutations in humans lead to …

The development of a functional vascular system is an essential process during vertebrate
embryogenesis. The blood vasculature, composed of a hierarchical branched network of …

Episodic Angioedema with Eosinophilia (Gleich syndrome) is a rare disease characterized
by periodic angioedema, fever, and marked eosinophilia. This study aimed to elucidate the …

Rationale Proper functionality of the circulatory system requires correct arteriovenous (AV)
endothelial cell (EC) differentiation. While Notch signaling and its downstream effector Hes …

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma that reflects a failure in muscle cells to
properly differentiate. Despite the addition of new treatments, there has only been an …