Publisher Summary This chapter focuses on the structure and function of alkyltransferase
protein. O 6-alkylguanine-DNA alkyltransferase is a remarkable protein that alone can, in a …

Cellular DNA is constantly subjected to modifications by intracellular and extracellular
chemicals, which can result in covalent changes. 1, 2 Alkylating agents are one group of …

O6-Alkylguanine-DNA alkyltransferase was rapidly and irreversibly inactivated by exposure
to O6-benzylguanine or the p-chlorobenzyl and p-methylbenzyl analogues. This inactivation …

The N-alkyl-and N-(2-haloethyl)-N-nitrosoureas represent one of the generally most useful
classes of anticancer agents, with a wide range of activities against various leukemias and …

Inherent and acquired resistance pathways account for the high rate of failure in cancer
chemotherapy. The mechanisms or pathways mediating resistance may be classified as …

Abstract O 6-methylguanine-DNA methyltransferase (MGMT) repairs the cancer
chemotherapy-relevant DNA adducts, O 6-methylguanine and O 6-chloroethylguanine …

PURPOSE The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair
protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or …

PURPOSE: We conducted a phase II trial of carmustine (BCNU) plus the O6-alkylguanine-
DNA alkyltransferase inhibitor O6-benzylguanine (O6-BG) to define the activity and toxicity …

Cell lines with constitutive levels of the DNA repair protein O 6-methylguanine-DNA
methyltransferase (O 6 MeGMT)(Mer+ phenotype) were less sensitive to the cytotoxic effects …

Tumour resistance and dose-limiting toxic effects restrict treatment with most
chemotherapeutic drugs. Elucidation of the mechanisms of these effects could permit the …