Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to
intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is …

Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on
human society worldwide. Among many factors responsible for LBP, intervertebral disc …

Painful intervertebral disc degeneration is mediated by inflammation that modulates
glycosylation and induces hyperinnervation and sensory sensitization, which result in …

Despite considerable efforts to develop cellular, molecular, and structural repair strategies
and restore intervertebral disk function after injury, the basic biology underlying …

There is a well-established link between cytokine expression and the progression of
intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor …

Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the
relationship is complex. This study assessed whether males and females have distinct …

Low back pain (LBP) is a leading cause of global disability. Multiple anatomical, cellular,
and molecular factors are implicated in LBP, including the degeneration of lumbar …

Abstract Background Context Painfulintervertebral disc degeneration is extremely common
and costly. Effective treatments are lacking because the nature of discogenic pain is …

The intervertebral disc (IVD) is the fibrocartilaginous joint located between each vertebral
body that confers flexibility and weight bearing capabilities to the spine. The IVD plays an …