Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

New photosensitizers for photodynamic therapy

H Abrahamse, MR Hamblin - Biochemical Journal, 2016 - portlandpress.com
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since
become a well-studied therapy for cancer and various non-malignant diseases including …

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

JM Dąbrowski, LG Arnaut - Photochemical & Photobiological Sciences, 2015 - pubs.rsc.org
Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and
adequate use of both to trigger biological mechanisms that can rapidly destroy the primary …

[HTML][HTML] Photodynamic therapy: current status and future directions

L Benov - Medical principles and practice, 2015 - karger.com
Photodynamic therapy (PDT) is a minimally invasive therapeutic modality used for the
management of a variety of cancers and benign diseases. The destruction of unwanted cells …

Precise two‐photon photodynamic therapy using an efficient photosensitizer with aggregation‐induced emission characteristics

B Gu, W Wu, G Xu, G Feng, F Yin… - Advanced …, 2017 - Wiley Online Library
Two‐photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of
treatment volumes, providing a target level that is unattainable with current therapeutic …

Efficient near-infrared photosensitizer with aggregation-induced emission for imaging-guided photodynamic therapy in multiple xenograft tumor models

J Dai, Y Li, Z Long, R Jiang, Z Zhuang, Z Wang… - ACS …, 2019 - ACS Publications
Photodynamic therapy (PDT) strategy has been widely used in tumor treatment, and the
reagents for reactive oxygen species (ROS) play a crucial role. Herein, we develop a …

Nanocomposite‐based photodynamic therapy strategies for deep tumor treatment

J Hu, Y Tang, AH Elmenoufy, H Xu, Z Cheng, X Yang - Small, 2015 - Wiley Online Library
Photodynamic therapy (PDT), as an emerging clinically approved modality, has been used
for treatment of various cancer diseases. Conventional PDT strategies are mainly focused …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

Reactive oxygen species in photodynamic therapy: mechanisms of their generation and potentiation

JM Dąbrowski - Advances in inorganic chemistry, 2017 - Elsevier
Reactive oxygen species (ROS) play key roles in cell signaling systems and homeostasis,
and they are also fundamental to photodynamic therapy (PDT). PDT efficacy can be affected …

[HTML][HTML] Bacteriochlorins and their metal complexes as NIR-absorbing photosensitizers: Properties, mechanisms, and applications

B Pucelik, A Sułek, JM Dąbrowski - Coordination Chemistry Reviews, 2020 - Elsevier
Bacterichlorins possess a characteristic intense electronic absorption in the near-infrared
part of the electromagnetic radiation (NIR) from 700 nm up to 900 nm, where endogenous …