Treg cell-based therapies: challenges and perspectives
C Raffin, LT Vo, JA Bluestone - Nature Reviews Immunology, 2020 - nature.com
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Y Togashi, K Shitara, H Nishikawa - Nature reviews Clinical oncology, 2019 - nature.com
Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
CTLA-4 in regulatory T cells for cancer immunotherapy
Simple Summary In the fight against cancer, immunotherapies have given great hope after
encouraging results in clinical investigations showing complete remission in some patients …
encouraging results in clinical investigations showing complete remission in some patients …
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
N Ohkura, S Sakaguchi - Cell research, 2020 - nature.com
Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
Development and maintenance of intestinal regulatory T cells
T Tanoue, K Atarashi, K Honda - Nature Reviews Immunology, 2016 - nature.com
Gut-resident forkhead box P3 (FOXP3)+ CD4+ regulatory T cells (Treg cells) are distinct from
those in other organs and have gut-specific phenotypes and functions. Whereas Treg cells …
those in other organs and have gut-specific phenotypes and functions. Whereas Treg cells …
Treg cells in health and autoimmune diseases: New insights from single cell analysis
C Scheinecker, L Göschl, M Bonelli - Journal of autoimmunity, 2020 - Elsevier
Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
Y Kitagawa, N Ohkura, Y Kidani, A Vandenbon… - Nature …, 2017 - nature.com
Abstract Most Foxp3+ regulatory T (T reg) cells develop in the thymus as a functionally
mature T cell subpopulation specialized for immune suppression. Their cell fate appears to …
mature T cell subpopulation specialized for immune suppression. Their cell fate appears to …
Treg cells in autoimmunity: from identification to Treg-based therapies
L Göschl, C Scheinecker, M Bonelli - Seminars in immunopathology, 2019 - Springer
Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …
tolerance and homeostasis. A major progress has been made in the identification and …