Understanding how movement is controlled by the CNS remains a major challenge, with
ongoing debate about basic features underlying this control. In current established views …

The central nervous system (CNS) may produce coordinated motor outputs via the
combination of motor modules representable as muscle synergies. Identification of muscle …

Muscle synergies are neural coordinative structures that function to alleviate the
computational burden associated with the control of movement and posture. In this …

After complete spinal cord transections that removed all supraspinal inputs in adult rats,
combinations of serotonergic agonists and epidural electrical stimulation were able to …

Despite distinct differences between walking and running, the two types of human
locomotion are likely to be controlled by shared pattern-generating networks. However, the …

Selecting the appropriate muscle pattern to achieve a given goal is an extremely complex
task because of the dimensionality of the search space and because of the nonlinear and …

We review experiments supporting the hypothesis that the vertebrate motor system produces
movements by combining a small number of units of motor output. Using a variety of …

A potential treatment for paralysis resulting from spinal cord injury is to route control signals
from the brain around the injury by artificial connections. Such signals could then control …

It has been proposed that movements are produced through groups of muscles, or motor
modules, activated by common neural commands. However, the neural origin of motor …

Production of voluntary movements relies critically on the functional integration of several
motor cortical areas, such as the primary motor cortex, and the spinal circuitries …