T‐cell receptor retrogenic mice: a rapid, flexible alternative to T‐cell receptor transgenic mice

ML Bettini, M Bettini, DAA Vignali - Immunology, 2012 - Wiley Online Library
The T‐cell receptor (TCR) is unique in its complexity. It determines not only positive (life) and
negative (death) selection in the thymus, but also mediates proliferation, anergy …

[HTML][HTML] T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3+ regulatory T cells

X Liu, P Nguyen, W Liu, C Cheng, M Steeves… - Immunity, 2009 - cell.com
The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3)+
regulatory T (Treg) and conventional T (Tconv) cell populations active at sites of …

The T-cell receptor is not hardwired to engage MHC ligands

SJ Holland, I Bartok, M Attaf… - Proceedings of the …, 2012 - National Acad Sciences
The bias of αβ T cells for MHC ligands has been proposed to be intrinsic to the T-cell
receptor (TCR). Equally, the CD4 and CD8 coreceptors contribute to ligand restriction by …

Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor

T Detanico, RA Heiser, K Aviszus… - The Journal of …, 2011 - journals.aai.org
Linked recognition of Ag by B and T lymphocytes is ensured in part by a state of tolerance
acquired by CD4 T cells to germline-encoded sequences within the B cell Ag receptor …

[PDF][PDF] The Role of Germline-encoded T Cell Receptor Complementarity Determining Regions in T Cell Selection and Function

S Holland - 2013 - core.ac.uk
Thesis Final - Corrected Page 1 1 The role of Germline-Encoded T cell Receptor Complementarity
Determining Regions in T cell Selection and Function By Stephen Holland Submitted for …