Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Sedentary life style is considered to be an independent risk factor for many disorders,
including development of type 2 diabetes, obesity, immune dysfunction, asthma, and …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of
adipose tissue and it has potentially protective properties in the development of obesity …

The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular
diseases owing to fat mass excess has been described. In recent years, muscle …

Irisin is a novel myokine and adipokine that has gained much attention recently due to its
mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor …

Exercise not only produces beneficial effects on muscle itself via various molecular
pathways, but also mediates the interaction between muscles and other organs in an …

Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a
controversy exists concerning irisin origin, regulation and function. To elucidate the …