Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

Importance of the field: 17β-Hydroxysteroid dehydrogenases (17β-HSDs) mainly catalyze
the reduction of C17-ketosteroids to their corresponding hydroxylated forms as well as the …

Oestradiol (E2) stimulates the growth of hormone‐dependent breast cancer. 17β‐
hydroxysteroid dehydrogenases (17β‐HSDs) catalyse the pre‐receptor …

Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …

Hydroxysteroid dehydrogenases (HSD) are a group of steroidogenic enzymes that are
involved in the steroid biosynthesis and metabolism. Four classes of HSDs, namely, 3β-, 11β …

Retinol (vitamin A) is a fat‐soluble nutrient indispensable for a harmonious mammalian
gestation. The absence or excess of retinol and its active derivatives [ie, the retinoic acids …

Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play
fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of …

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) plays a pivotal role in the local
synthesis of the most potent estrogen estradiol. Its expression is a prognostic marker for the …

The 17β-hydroxysteroid dehydrogenases (17β-HSDs) are involved in the regulation of
estrogens and androgens by catalyzing the reduction of 17-ketosteroids or the oxidation of …

In search for specific drugs against steroid-dependent cancers we have developed a novel
set of potent inhibitors of steroidogenic human 17β-hydroxysteroid dehydrogenase type 1 …