Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

The two major lineages of classical dendritic cells (cDCs) express and require either IRF8 or
IRF4 transcription factors for their development and function. IRF8-dependent cDCs promote …

Recent studies into the global causes of severe diarrhoea in young children have identified
the protozoan parasite Cryptosporidium as the second most important diarrhoeal pathogen …

The AP1 transcription factor Batf3 is required for homeostatic development of CD8α+
classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens …

CD8α+ dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived
from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by …

Background The obligate intracellular parasite Toxoplasma gondii establishes a life-long
chronic infection within any warm-blooded host. After ingestion of an encysted parasite, T …

The physiologic importance of autophagy proteins for control of mammalian bacterial and
parasitic infection in vivo is unknown. Using mice with granulocyte-and macrophage-specific …

Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent
on the activation of the innate immune response. In this study, we investigated the role of …

Toxoplasma gondii is a highly successful global pathogen that is remarkable in its ability to
infect nearly any nucleated cell in any warm‐blooded animal. Infection with T. gondii …