Alternative splicing is a tightly regulated biological process by which the number of gene
products for any given gene can be greatly expanded. Genomic variants in splicing …

Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by
allowing one gene to generate multiple distinct protein isoforms. It adds another regulation …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Alternative usage of transcript isoforms from the same gene has been hypothesized as an
important feature in cancers. However, differential usage of gene transcripts between …

Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …

Alternative splicing provides a major mechanism to generate protein diversity. Increasing
evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide …

As an essential part of central dogma, RNA delivers genetic and regulatory information and
reflects cellular states. Based on high-throughput sequencing technologies, cumulating data …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

The success of checkpoint blockade therapy against cancer has unequivocally shown that
cancer cells can be effectively recognized by the immune system and eliminated. However …

Abstract Rationale: Long extracellular RNAs (exRNAs) in plasma can be profiled by new
sequencing technologies, even with low abundance. However, cancer-related exRNAs and …