Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

Many genomic studies have revealed associations between the gut microbiota composition
and host metabolism. These observations led to the idea that a causal relationship could …

Myeloid cells comprise a major component of the tumor microenvironment (TME) that
promotes tumor growth and immune evasion. By employing a small-molecule inhibitor of …

INTRODUCTION Extensive tumor sequencing efforts have transformed the way in which
cancer driver genes are identified. Appropriate statistical modeling is crucial for …

Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

Summary The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of
CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive. Herein we …

Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women
worldwide. While BrCa treatment has been shown to be highly successful if detected at an …

The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Colorectal cancer is a major cause of mortality worldwide. Chemotherapy and radiation
remain standard treatment for locally advanced disease, with current immune-targeting …