Toolbox for distal C–H bond functionalizations in organic molecules

SK Sinha, S Guin, S Maiti, JP Biswas, S Porey… - Chemical …, 2021 - ACS Publications
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Hexafluoroisopropanol: the magical solvent for Pd-catalyzed C–H activation

T Bhattacharya, A Ghosh, D Maiti - Chemical Science, 2021 - pubs.rsc.org
Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …

Recent development in transition metal-catalysed C–H olefination

W Ali, G Prakash, D Maiti - Chemical Science, 2021 - pubs.rsc.org
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …

The crucial role of silver (i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

RL de Carvalho, EBT Diogo, SL Homölle… - Chemical Society …, 2023 - pubs.rsc.org
Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …

Pd-catalyzed regioselective activation of C (sp 2)–H and C (sp 3)–H bonds

W Ali, GA Oliver, DB Werz, D Maiti - Chemical Society Reviews, 2024 - pubs.rsc.org
Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Recent advances in external-directing-group-free C–H functionalization of carboxylic acids without decarboxylation

J Das, DK Mal, S Maji, D Maiti - ACS Catalysis, 2021 - ACS Publications
The selective functionalization of C–H bonds is an extremely important topic in present-day
organic synthesis, as it utilizes the most abundant portion of a molecule as a tool for …

Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation

Q Zhang, BF Shi - Chemical Science, 2021 - pubs.rsc.org
Directing group assistance provided a paradigm for controlling site-selectivity in transition
metal-catalyzed C–H functionalization reactions. However, the kinetically and …

PdII–Catalyzed Site-selective β- and γ-C(sp3)–H Arylation of Primary Aldehydes Controlled by Transient Directing Groups

YH Li, Y Ouyang, N Chekshin… - Journal of the American …, 2022 - ACS Publications
Pd (II)-catalyzed site-selective β-and γ-C (sp3)–H arylation of primary aldehydes is
developed by rational design of L, X-type transient directing groups (TDG). External 2 …

Late-stage functionalization of peptides via a palladium-catalyzed C (sp 3)–H activation strategy

BB Zhan, MX Jiang, BF Shi - Chemical Communications, 2020 - pubs.rsc.org
Peptides hold great promise in proteomics, diagnostics and drug discovery. While natural
peptides continue to be of key importance, chemically modified unnatural peptides have …