Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which
enable adaptation to metastatic microenvironments and resistance to therapies …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group
box-containing (SOX) proteins, most of which contribute to cell type specification and …

Tumor cells, including cancer stem cells (CSCs) resistant to radio-and chemotherapy, must
enhance metabolism to meet the extra energy demands to repair and survive such …

The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of
their continuous presence during development and in the differentiated state they shape the …

Melanoma onset and progression are associated with a high variety of activating mutations
in the MAPK-pathway, most frequently involving BRAF (35–45%) and NRAS (15–25%) …

Myelination is an evolutionary recent differentiation program that has been independently
acquired in vertebrates by Schwann cells in the peripheral nervous system and …

Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer
cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action …

Melanoma is an aggressive malignancy of melanocytes and most commonly arises in the
skin. In 2002, BRAF gene mutations were identified in melanoma, and this finding resulted in …