The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Type 2 diabetes continues to negatively impact the health of millions. The inability to
respond to insulin to clear blood glucose (insulin resistance) is a key pathogenic driver of …

Dicarbonyl stress occurs when dicarbonyl metabolites (ie, methylglyoxal, glyoxal and 3-
deoxyglucosone) accumulate as a consequence of their increased production and/or …

We hypothesized that the maintenance of vascular homeostasis is critically dependent on
the expression and reciprocal regulation of caveolin-1 (Cav-1) and endothelial nitric oxide …

The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to
proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating …

Hexokinase-2 (HK2) was recently found to produce increased metabolic flux through
glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation …

Since the discovery of the nuclear factor erythroid-derived 2-like 2 (Nrf2) transcription factor
thirty years ago, it has been shown that it regulates more than 250 genes involved in a …

The obesity rate in the United States is 42.4% and has become a national epidemic. Obesity
is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age …

Glyoxalase-1 (GLO1) is a ubiquitously expressed cytosolic protein which plays a role in the
natural maintenance of cellular health and is abundantly expressed in human skeletal …

Obesity prevalence in the US has nearly tripled since 1975 and a parallel increase in
prevalence of type 2 diabetes (T2D). Obesity promotes a myriad of metabolic derangements …