Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation

J Zhao, G Tian, H Qu - Biomedicines, 2023 - mdpi.com
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical
manufacturing and a potential alternative method to batch granulation processes. It has …

Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation

M Peeters, AAB Jiménez, K Matsunami, M Ghijs… - International Journal of …, 2024 - Elsevier
In the last few years, twin-screw wet granulation (TSWG) has become one of the key
continuous pharmaceutical unit operations. Despite the many studies that have been …

Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability

M Peeters, AAB Jiménez, K Matsunami… - International Journal of …, 2023 - Elsevier
Twin-screw wet granulation (TSWG) stands out as a promising continuous alternative to
conventional batch fluid bed-and high shear wet granulation techniques. Despite its …

Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing

SP Forster, E Dippold, A Haser, D Emanuele, R Meier - Pharmaceutics, 2023 - mdpi.com
The pharmaceutical industry is in the midst of a transition from traditional batch processes to
continuous manufacturing. However, the challenges in making this transition vary …

[HTML][HTML] Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations: Calibration, sensitivity analysis, and model-driven workflow

N Bala, J Corrigan, J Meyer, M Schongut… - International Journal of …, 2024 - Elsevier
Wet granulation, a particle size enlargement process, can significantly enhance the critical
quality attributes of powders and improve the ability to form tablets in pharmaceutical …

[HTML][HTML] Systematic investigation of the impact of screw elements in continuous wet granulation

K Kiricenko, R Meier, P Kleinebudde - International Journal of …, 2024 - Elsevier
Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for
granules as final dosage form or as an intermediate before tableting or capsule filling. A …

Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map

L Kotamarthy, S Karkala, A Dan, AD Román-Ospino… - Pharmaceutics, 2024 - mdpi.com
Twin-screw granulation (TSG) is an emerging continuous wet granulation technique that has
not been widely applied in the industry due to a poor mechanistic understanding of the …

Advancing Continuous Manufacturing: The Role of Process Analytical Technology in Process Development

SR Henson - 2024 - search.proquest.com
The pharmaceutical industry is actively pursuing technologies which improve manufacturing
processes with the goal of producing high-quality pharmaceutical products for patients …

[引用][C] Increasing the applicability of population balance models in continuous pharmaceutical twin-screw wet granulation

AA Barrera Jiménez - 2022 - biblio.ugent.be
The pharmaceutical industry dedicates much effort to develop products that save and
prolong the lives of patients. For that reason, the industry invests considerable amounts of …