Slow-binding inhibition (SBI) of enzymes is characterized by slow establishment of enzyme-
inhibitor equilibrium. Cholinesterases (ChEs) display slow onset of inhibition with certain …

The prohormone convertases (PC) 1/3 and 2 are calcium-activated eukaryotic subtilisins
with low pH optima which accomplish the limited proteolysis of peptide hormone precursors …

Cholinesterases (ChEs) display a hysteretic behavior with certain substrates and inhibitors.
Kinetic cooperativity in hysteresis of ChE-catalyzed reactions is characterized by a lag or …

The observation that the two active forms of proprotein convertase 1/3 (PC1/3) were
differentially expressed in beta cells of normal islets raised the possibility that this …

Satiety and appetite signaling are accomplished by circulating peptide hormones. These
peptide hormones require processing from larger precursors to become bioactive, often by …

Proprotein convertases (PCs) are involved in the pathogenesis of various diseases, making
them promising drug targets. Most assays for PCs have been performed with few standard …

Environmental nutrients control bacterial biofilm homeostasis, by regulating the intracellular
levels of c-di-GMP. One component transducers can sense different classes of small …

In Trypanosoma cruzi, the causal agent of Chagas disease, the first six or seven steps of
glycolysis are compartmentalized in glycosomes, which are authentic but specialized …

При взаимодействии с определенными субстратами и ингибиторами холинэстеразы
проявляют т. н. гистере-зисное поведение. Кинетическая кооперативность в …

In pancreatic beta cells, proinsulin (ProIN) undergoes folding in endoplasmic reticulum/Golgi
system and is translocated to secretory vesicles for processing into insulin and C-peptide by …