Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme disease pathogenesis

J Coburn, B Garcia, LT Hu, MW Jewett… - Current issues in …, 2021 - mdpi.com
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

The effect of bacterial chemotaxis on host infection and pathogenicity

MA Matilla, T Krell - FEMS Microbiology Reviews, 2018 - academic.oup.com
Chemotaxis enables microorganisms to move according to chemical gradients. Although
this process requires substantial cellular energy, it also affords key physiological benefits …

A selective antibiotic for Lyme disease

N Leimer, X Wu, Y Imai, M Morrissette, N Pitt… - Cell, 2021 - cell.com
Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …

Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion

JA Hyde - Frontiers in immunology, 2017 - frontiersin.org
Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage,
inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic …

Multipartite genome of Lyme disease Borrelia: structure, variation and prophages

I Schwartz, G Margos, SR Casjens, WG Qiu… - Current issues in …, 2021 - mdpi.com
All members of the Borrelia genus that have been examined harbour a linear chromosome
that is about 900 kbp in length, as well as a plethora of both linear and circular plasmids in …

Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization

S Narasimhan, TJ Schuijt, NM Abraham… - Nature …, 2017 - nature.com
Abstract The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes
scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we …

Gene regulation and transcriptomics

DS Samuels, MC Lybecker, XF Yang, Z Ouyang… - Current issues in …, 2021 - mdpi.com
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

MJ Caimano, AM Groshong, A Belperron… - Frontiers in …, 2019 - frontiersin.org
Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

Interaction of the Lyme disease spirochete with its tick vector

MJ Caimano, D Drecktrah, F Kung… - Cellular …, 2016 - Wiley Online Library
Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related
genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in …