Best practices for analysing microbiomes

R Knight, A Vrbanac, BC Taylor, A Aksenov… - Nature Reviews …, 2018 - nature.com
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

Molecular networking as a drug discovery, drug metabolism, and precision medicine strategy

RA Quinn, LF Nothias, O Vining, M Meehan… - Trends in …, 2017 - cell.com
Molecular networking is a tandem mass spectrometry (MS/MS) data organizational
approach that has been recently introduced in the drug discovery, metabolomics, and …

High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

Y Lai, CW Liu, Y Yang, YC Hsiao, H Ru, K Lu - Nature communications, 2021 - nature.com
The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota.
While emerging studies support that microbiota regulates brain function with a few molecular …

Specialized metabolites from the microbiome in health and disease

G Sharon, N Garg, J Debelius, R Knight, PC Dorrestein… - Cell metabolism, 2014 - cell.com
The microbiota, and the genes that comprise its microbiome, play key roles in human health.
Host-microbe interactions affect immunity, metabolism, development, and behavior, and …

Role of bacterial volatile compounds in bacterial biology

B Audrain, MA Farag, CM Ryu… - FEMS microbiology …, 2015 - academic.oup.com
Bacterial interactions with neighboring microorganisms via production of small metabolites
enable bacteria to respond and adapt to environmental changes. The study of intercellular …

“It takes a village”: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms

G Orazi, GA O'Toole - Journal of Bacteriology, 2019 - Am Soc Microbiol
Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these
infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to …

Exhaled molecular fingerprinting in diagnosis and monitoring: validating volatile promises

AW Boots, LD Bos, MP van der Schee… - Trends in molecular …, 2015 - cell.com
Medical diagnosis and phenotyping increasingly incorporate information from complex
biological samples. This has promoted the development and clinical application of non …

Exhaled volatile organic compounds of infection: a systematic review

WM Ahmed, O Lawal, TM Nijsen… - ACS Infectious …, 2017 - ACS Publications
With heightened global concern of microbial drug resistance, advanced methods for early
and accurate diagnosis of infection are urgently needed. Analysis of exhaled breath volatile …

Breathomics in the setting of asthma and chronic obstructive pulmonary disease

LD Bos, PJ Sterk, SJ Fowler - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Exhaled breath contains thousands of volatile organic compounds that reflect the metabolic
process occurring in the host both locally in the airways and systemically. They also arise …

Polymicrobial–host interactions during infection

WH Tay, KKL Chong, KA Kline - Journal of molecular biology, 2016 - Elsevier
Microbial pathogenesis research has, historically, focused on the study of infections as
monomicrobial events. However, the advent of next generation sequencing and culture …