Histone exchange, chromatin structure and the regulation of transcription
S Venkatesh, JL Workman - Nature reviews Molecular cell biology, 2015 - nature.com
The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
Histone marks in the 'driver's seat': functional roles in steering the transcription cycle
LA Gates, CE Foulds, BW O'malley - Trends in biochemical sciences, 2017 - cell.com
Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
Intragenic DNA methylation prevents spurious transcription initiation
In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …
promoter suppresses gene expression, but the functional role of gene-body DNA …
Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferon antiviral activity
K Chen, J Liu, S Liu, M Xia, X Zhang, D Han, Y Jiang… - Cell, 2017 - cell.com
Interferon-α (IFNα) signaling is essential for antiviral response via induction of IFN-
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …
[HTML][HTML] Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation
Summary Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer
types, identifying it as an important therapeutic target. Here we identify a synthetic lethal …
types, identifying it as an important therapeutic target. Here we identify a synthetic lethal …
Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity
T Dahlet, A Argüeso Lleida, H Al Adhami… - Nature …, 2020 - nature.com
Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
Dealing with pervasive transcription
TH Jensen, A Jacquier, D Libri - Molecular cell, 2013 - cell.com
Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …
found RNAs have functions and how many are byproducts of functional, or spurious …
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
S Carvalho, AC Vítor, SC Sridhara, FB Martins… - elife, 2014 - elifesciences.org
Histone modifications establish the chromatin states that coordinate the DNA damage
response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 …
response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 …
SETD5 regulates chromatin methylation state and preserves global transcriptional fidelity during brain development and neuronal wiring
Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic
spectrum disorders. However, the mechanisms by which SETD5 regulates brain …
spectrum disorders. However, the mechanisms by which SETD5 regulates brain …
Understanding histone H3 lysine 36 methylation and its deregulation in disease
Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …
chromatin to distinctive domains and the regulation of a wide range of biological processes …