Mechanism and regulation of the nonsense-mediated decay pathway
N Hug, D Longman, JF Cáceres - Nucleic acids research, 2016 - academic.oup.com
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story
F He, A Jacobson - Annual review of genetics, 2015 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
[HTML][HTML] Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
S Chakrabarti, U Jayachandran, F Bonneau, F Fiorini… - Molecular cell, 2011 - cell.com
Upf1 is a crucial factor in nonsense-mediated mRNA decay, the eukaryotic surveillance
pathway that degrades mRNAs containing premature stop codons. The essential RNA …
pathway that degrades mRNAs containing premature stop codons. The essential RNA …
The branched nature of the nonsense-mediated mRNA decay pathway
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding
Z Yi, RM Arvola, S Myers, CN Dilsavor… - The EMBO …, 2022 - embopress.org
Nonsense‐mediated mRNA decay (NMD) is governed by the three conserved factors—
UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is …
UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is …
Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway
The mechanisms dictating whether a cell proliferates or differentiates have undergone
intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central …
intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central …
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs
Recruitment of the UPF1 nonsense-mediated mRNA decay (NMD) factor to target mRNAs
was initially proposed to occur through interaction with release factors at terminating …
was initially proposed to occur through interaction with release factors at terminating …
High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection
Nonsense-mediated mRNA decay (NMD) plays an important role in eukaryotic gene
expression, yet the scope and the defining features of NMD-targeted transcripts remain …
expression, yet the scope and the defining features of NMD-targeted transcripts remain …
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question
Nonsense-mediated mRNA decay (NMD) is a well-studied cellular quality-control pathway. It
decreases the half-lives of eukaryotic mRNAs that aberrantly contain premature termination …
decreases the half-lives of eukaryotic mRNAs that aberrantly contain premature termination …
Unique aspects of plant nonsense-mediated mRNA decay
O Shaul - Trends in plant science, 2015 - cell.com
Nonsense-mediated mRNA Decay (NMD) is a eukaryotic quality-control mechanism that
governs the stability of both aberrant and normal transcripts. Although plant and mammalian …
governs the stability of both aberrant and normal transcripts. Although plant and mammalian …