The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus
(T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in …

Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …

Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …

Objective To investigate the differences in bone turnover between diabetic patients and
controls. Design A systematic review and meta-analysis. Methods A literature search was …

Abstract Purpose of Review Diabetes mellitus is defined by elevated blood glucose levels
caused by changes in glucose metabolism and, according to its pathogenesis, is classified …

Background Diabetes mellitus is associated with an increased risk of fractures, which is not
explained by bone mineral density. Other markers as bone turnover markers (BTMs) may be …

There is growing evidence that the higher fracture rate observed in patients with type 2
diabetes mellitus (T2DM) is associated with normal, or even increased, areal bone mineral …

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but …

Type 2 diabetes is associated with increased fracture risk and the mechanisms underlying
the detrimental effects of diabetes on skeletal health are only partially understood …

Insulin-like growth factor 1 (IGF-1) is a determinant of bone mass and is inversely associated
with vertebral fractures (VFs). Sclerostin regulates bone formation by inhibiting Wnt/β …