1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …

The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s) …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Snakebite envenomation is a neglected global health problem, causing substantial mortality,
disability, and psychological morbidity, especially in rural tropical and subtropical zones …

Envenomation via snakebites is an important public health problem in many tropical and
subtropical countries that, in addition to mortality, can result in permanent sequelae as a …

Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …

Animal venoms comprise a complex mixture of components that affect several biological
systems. Based on the high selectivity for their molecular targets, these components are also …