The use of bacterial cells as agents of medical therapy has a long history. Research that was
ignited over a century ago with the accidental infection of cancer patients has matured into a …

Engineered bacterial therapies that target the tumor immune landscape offer a new class of
cancer immunotherapy. Salmonella enterica and Listeria monocytogenes are two species of …

The workshop on vaccine adjuvants was held in July of 2009 at the European Commission
in Brussels, with the goal of identifying key scientific priorities as they pertain to the …

Adjuvants contribute to enhancing and shaping the vaccine immune response through
different modes of action. Here early biomarkers of adjuvanticity after primary immunization …

The current paradigm that subunit vaccines require adjuvants to optimally activate innate
immunity implies that increased vaccine reactogenicity will invariably be linked to improved …

The chemistries within phagosomes of APCs mediate microbial destruction as well as
generate peptides for presentation on MHC class II. The antimicrobial effector NADPH …

The pathogenesis of bacteraemia after challenge with one million pneumococci of three
isogenic variants was investigated. Sequential analyses of blood samples indicated that …

Since more than a decade, pharmaceutical researchers endeavor to develop an effective,
safe and target-specific drug delivery system to potentiate the therapeutic actions and …

Combinations of different delivery routes for priming and boosting represent vaccination
strategies that can modulate magnitude, quality, and localization of the immune response. A …

Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical
importance for the rational design of vaccination strategies. In this study, transcriptomics was …