Smart contact lenses as wearable ophthalmic devices for disease monitoring and health management

H Seo, WG Chung, YW Kwon, S Kim, YM Hong… - Chemical …, 2023 - ACS Publications
The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Role of inflammation in diabetic retinopathy

A Rübsam, S Parikh, PE Fort - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

Activation and role of astrocytes in ischemic stroke

XY Shen, ZK Gao, Y Han, M Yuan, YS Guo… - Frontiers in cellular …, 2021 - frontiersin.org
Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

Brain‐targeted liposomes loaded with monoclonal antibodies reduce alpha‐synuclein aggregation and improve behavioral symptoms in Parkinson's disease

M Sela, M Poley, P Mora‐Raimundo… - Advanced …, 2023 - Wiley Online Library
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

M Hara, K Kobayakawa, Y Ohkawa, H Kumamaru… - Nature medicine, 2017 - nature.com
Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes,
which eventually become scar-forming astrocytes that can impair axonal regeneration and …

Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

J Dai, PJ Cimino, KH Gouin III, CA Grzelak, A Barrett… - Nature cancer, 2022 - nature.com
Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the
brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

Z Liu, M Chopp - Progress in neurobiology, 2016 - Elsevier
Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

A layered spiking neural system for classification problems

G Zhang, X Zhang, H Rong, P Paul, M Zhu… - … journal of neural …, 2022 - World Scientific
Biological brains have a natural capacity for resolving certain classification tasks. Studies on
biologically plausible spiking neurons, architectures and mechanisms of artificial neural …

Immune and neuroendocrine mechanisms of stress vulnerability and resilience

C Ménard, ML Pfau, GE Hodes, SJ Russo - Neuropsychopharmacology, 2017 - nature.com
Diagnostic criteria for mood disorders including major depressive disorder (MDD) largely
ignore biological factors in favor of behavioral symptoms. Compounding this paucity of …