Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Azetidines represent one of the most important four-membered heterocycles used in organic
synthesis and medicinal chemistry. The reactivity of azetidines is driven by a considerable …

Natural product structure and fragment-based compound development inspire pseudo-
natural product design through different combinations of a given natural product fragment …

There is a great need for innovative new medicines to treat unmet medical needs. The
discovery and development of innovative new medicines is extremely difficult, costly, and …

Natural products (NPs) inspire the design and synthesis of novel biologically relevant
chemical matter, for instance through biology‐oriented synthesis (BIOS). However, BIOS is …

It is challenging to incorporate stereochemical diversity and topographic complexity into
DNA-encoded libraries (DELs) because DEL syntheses cannot fully exploit the capabilities …

Chirality is an inherent aspect of biology, and interactions between biomolecules are often
influenced by stereochemistry and topographic complexity. This has implications for how …

Profiling approaches such as gene expression or proteome profiling generate small-
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …

Despite the favorable properties that azetidine rings can engender on drug‐compounds,
methods for the diversity‐oriented synthesis of azetidine‐based structures are significantly …

Abstract 'Cell Painting'is an imaging-based high-throughput phenotypic profiling (HTPP)
method in which cultured cells are fluorescently labeled to visualize subcellular structures …