[HTML][HTML] Comorbidities of atopic dermatitis—what does the evidence say?

JP Thyssen, AS Halling, P Schmid-Grendelmeier… - Journal of Allergy and …, 2023 - Elsevier
Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic
comorbidities. There has been a growing interest in this area of AD, because presence or …

A review of safety outcomes from clinical trials of baricitinib in rheumatology, dermatology and COVID-19

T Bieber, E Feist, AD Irvine, M Harigai, E Haladyj… - Advances in …, 2022 - Springer
Baricitinib is an oral, selective inhibitor of Janus kinase (JAK) 1/JAK2 that transiently and
reversibly inhibits many proinflammatory cytokines. This mechanism is a key mediator in a …

American Academy of Dermatology Guidelines: awareness of comorbidities associated with atopic dermatitis in adults

DMR Davis, AM Drucker, A Alikhan, L Bercovitch… - Journal of the American …, 2022 - Elsevier
Background Studies found associations between atopic dermatitis (AD) and various
comorbidities. Objective To appraise evidence of the association between AD and …

[HTML][HTML] Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a …

EL Simpson, JR Parnes, D She, S Crouch… - Journal of the American …, 2019 - Elsevier
Background Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody,
targets thymic stromal lymphopoietin, a cytokine that is implicated in the pathogenesis of …

Cardiovascular and venous thromboembolic risk with JAK inhibitors in immune-mediated inflammatory skin diseases: a systematic review and meta-analysis

JP Ingrassia, MH Maqsood, JM Gelfand… - JAMA …, 2024 - jamanetwork.com
Importance Janus kinase (JAK) inhibitors are an effective treatment option for patients with
certain skin-related conditions, such as atopic dermatitis, alopecia areata, and vitiligo, but …

Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials

T Bieber, JP Thyssen, K Reich… - Journal of the …, 2021 - Wiley Online Library
Background Janus kinase (JAK) inhibition is a new mode of action in atopic dermatitis (AD);
clarity about drug class safety considerations in the context of AD is important. Baricitinib, an …

The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature

AB Pavel, L Zhou, A Diaz, B Ungar, J Dan, H He… - Journal of the American …, 2020 - Elsevier
Background Moderate-to-severe atopic dermatitis (AD) is increasingly recognized as a
systemic disease, largely due to proteomic blood studies. There are growing efforts to …

Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches

M Moyle, F Cevikbas, JL Harden… - Experimental …, 2019 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is
characterized by persistent itch and marked redness. AD is associated with an increased …

[HTML][HTML] Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study

Y Schonmann, KE Mansfield, JF Hayes… - The Journal of Allergy …, 2020 - Elsevier
Background Atopic eczema is a common and debilitating condition associated with
depression and anxiety, but the nature of this association remains unclear. Objective To …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …