Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins
and cofactors of the electron transport chain. The initial idea that the respiratory chain …

Proteins that exsert physiological functions during being translated have been discovered
from prokaryotes to eukaryotes. These proteins, also called regulatory nascent chains, are …

Regulatory arrest peptides interact with specific residues on bacterial ribosomes and arrest
their own translation. Here, we analyse over 30,000 bacterial genome sequences to identify …

Two multisubunit protein complexes for membrane protein insertion were recently identified
in the endoplasmic reticulum (ER): the guided entry of tail anchor proteins (GET) complex …

How chaperones, insertases and translocases facilitate insertion and folding of complex
cytoplasmic proteins into cellular membranes is not fully understood. Here we utilize single …

Abstract YidC/Oxa1/Alb3 are essential proteins that operate independently or cooperatively
with the Sec machinery during membrane protein insertion in bacteria, archaea and …

The rise of the computer as a powerful tool for model building and refinement has
revolutionized the field of structure determination for large biomolecular systems. Despite …

Abstract α-Helical integral membrane proteins comprise approximately 25% of the proteome
in all organisms. The membrane proteome is highly diverse, varying in the number …

Summary The YidC/Oxa1/Alb3 family of membrane proteins function to insert proteins into
membranes in bacteria, mitochondria, and chloroplasts. Recent X-ray structures of YidC …

The conserved SecYEG protein-conducting channel and the accessory proteins SecDF-
YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion …